Daniel C Link Selected Research

Cyclic neutropenia

12/2017	Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia.
1/2015	The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.
1/2008	Severe congenital neutropenia and the unfolded protein response.
12/2007	Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
11/2002	Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.

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Daniel C Link Research Topics

Disease

18	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 11/2003
16	Neoplasms (Cancer) 12/2022 - 05/2008
12	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2022 - 11/2002
10	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 10/2022 - 07/2010
7	Leukemia 12/2018 - 06/2009
5	Cyclic neutropenia 12/2017 - 11/2002
4	Inflammation (Inflammations) 10/2020 - 01/2013
4	Ischemia 07/2010 - 10/2006
3	severe chronic Neutropenia 12/2022 - 01/2008
3	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 08/2008
3	Infections 05/2015 - 04/2007
2	Neutropenia 12/2022 - 01/2015
2	Disease Progression 09/2018 - 01/2018
2	Chromosome Aberrations (Chromosome Abnormalities) 11/2016 - 02/2015
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2015 - 10/2012
2	Acute Promyelocytic Leukemia 06/2009 - 02/2007
1	Autoimmune Diseases (Autoimmune Disease) 12/2022
1	Aplastic Anemia (Anemia, Hypoplastic) 12/2022
1	Primary Myelofibrosis (Myelosclerosis) 01/2022
1	Cryopyrin-Associated Periodic Syndromes 11/2018
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 12/2011
1	Splenomegaly 12/2011
1	Ovarian Neoplasms (Ovarian Cancer) 04/2011
1	Uniparental Disomy 04/2011
1	Prostatic Neoplasms (Prostate Cancer) 04/2011
1	Sepsis (Septicemia) 07/2010
1	Carcinoma (Carcinomatosis) 10/2009
1	Necrosis 10/2009
1	Genetic Translocation (Chromosomal Translocation) 06/2009
1	Peripheral Vascular Diseases (Peripheral Vascular Disease) 05/2009
1	Metabolic Bone Diseases (Osteopenia) 11/2008
1	Pseudomonas Infections 04/2007
1	Cystic Fibrosis (Mucoviscidosis) 04/2007
1	Bacterial Infections (Bacterial Infection) 12/2006
1	Pathologic Constriction (Stenosis) 10/2006

Drug/Important Bio-Agent (IBA)

14	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2022 - 10/2006
6	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2015 - 11/2002
6	DNA (Deoxyribonucleic Acid)IBA 12/2014 - 11/2003
4	RNA (Ribonucleic Acid)IBA 10/2022 - 07/2010
3	Decitabine FDA Link 01/2022 - 11/2016
2	Alkylating AgentsIBA 01/2020 - 12/2014
2	MicroRNAs (MicroRNA)IBA 10/2013 - 12/2010
2	Complement System Proteins (Complement)IBA 09/2009 - 08/2009
2	Proteins (Proteins, Gene)FDA Link 06/2009 - 01/2008
2	plerixafor FDA Link 08/2008 - 10/2006
2	Granulocyte Colony-Stimulating Factor Receptors (G-CSF Receptor)IBA 03/2008 - 10/2006
1	JNK Mitogen-Activated Protein KinasesIBA 01/2022
1	Endopeptidase ClpIBA 01/2022
1	InterleukinsIBA 11/2018
1	InflammasomesIBA 11/2018
1	Interleukin-18 (Interleukin 18)IBA 11/2018
1	CohesinsIBA 11/2015
1	LipidsIBA 01/2015
1	Ether (Diethyl Ether)IBA 01/2015
1	EnzymesIBA 01/2015
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2015
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2015
1	CytokinesIBA 01/2013
1	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 10/2012
1	Peptide Hydrolases (Proteases)FDA Link 12/2011
1	RNA Splicing FactorsIBA 12/2011
1	NucleotidesIBA 04/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2009
1	Pharmaceutical PreparationsIBA 10/2009
1	Oxi 4503IBA 10/2009
1	Messenger RNA (mRNA)IBA 06/2009
1	Retinoic Acid Receptor alphaIBA 06/2009
1	Chemotactic FactorsIBA 09/2008
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2008
1	Phosphotransferases (Kinase)IBA 05/2008
1	Sepharose (Agarose)IBA 04/2007
1	erucylphosphocholineIBA 10/2006

Therapy/Procedure

15	Therapeutics 12/2022 - 11/2008
9	Drug Therapy (Chemotherapy) 12/2021 - 10/2009
3	Transplantation 12/2021 - 05/2009
3	Hematopoietic Stem Cell Transplantation 12/2021 - 09/2018
2	Radiotherapy 10/2020 - 02/2015
1	Homologous Transplantation 12/2018
1	Cell Transplantation 01/2018
1	Induction Chemotherapy 02/2016
1	Ligation 05/2009